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Team 3 - Oncogenesis of cutaneous lymphomas (26 November 2020)

functional and experimental assays to analyze the lymphoma cell hallmarks such as proliferation, apoptosis resistance, migration and invasion. Each principal investigator with its students develops its own ... Cutaneous lymphoma as a general model to study lymphoid cells oncogenesis

The word from the Director (10 April 2017)

to find new biomarkers and targets of clinical relevance. We are all using experimental approaches in mice or cancer cell line models to characterize cancer cell hallmarks in three major cancer types

Structure of the unit (29 November 2020)

strong connections with the University Hospital of Bordeaux and is using relevant experimental models in mice or using cell lines of the three cancer types: liver carcinoma, gastric cancer linked

Group 1- MALT Lymphoma (PI: P. Lehours) (20 November 2020)

The striking facts of the P. Lehours’s team can be resumed as follows. - A new model of lymphomagenesis was implemented in our laboratory, based on Helicobacter species infection (H. pylori or H

Group 2- Helicobacter pylori infection and gastric carcinoma (PI: Christine Varon and Emilie Bessède) (20 November 2020)

infection induces the emergence of CD44+ cells with CSC properties via an epithelial to mesenchymal transition (EMT) (Bessède et al, Oncogene 2014). In this context, using a transgenic mouse model in which

Group 3- Enterohepatic Helicobacters CDT and Helicobacter phylogeny (PI: Armelle Ménard) (20 November 2020)

(Péré-Védrenne P et al., J Infect Dis 2016), as well as senescence and cell endoreplication in xenograft mouse models (Péré-Védrenne P et al., Front Cell Infect Microbiol 2017). We showed that, in vivo

1st Discoidin Domain Receptors Meeting (23 January 2019)

, pharmacological inhibition of DDRs results in significant therapeutic benefit in some pre-clinical models that recapitulate human disease. Yet, there is an urgent need to increase our current understanding

Team 2 - Helicobacter infection: Inflammation and Cancer (27 January 2022)

. Our main research axes: Gastric MALT lymphoma and in particular on inflammatory and molecular responses in animal model of gastric MALT lymphoma development (Philippe Lehours) Cancer stem cells

Group 4 - Helicobacter infection and Alzheimer’s disease (PI: Claire Roubaud-Baudron) (20 November 2020)

Soc 2013). Because of the possibility of confounding factors, we used a murine model of infection with H. pylori. Mice predisposed to AD (transgenic mice) infected by H. pylori presented an increased

Group V. Moreau (25 February 2022)

as important for cancer invasion and metastasis. Our group uses a wide range of biochemical, cell biological methods and animal models to study how actin cytoskeleton is regulated and involved in hepatocellular